Synovial tissues concentrate secreted APRIL

Synovial tissues concentrate secreted APRIL

INTRODUCTION A proliferation-inducing ligand (APRIL) from the TNF family, owing to its role in the generation and survival of plasma cells (PCs), is currently targeted for rheumatoid arthritis (RA) treatment. However, little is known about APRIL expression in RA lesions, hampering our understanding of the way APRIL may modulate this autoimmune disease. METHODS We performed immunological stain...

Haemosiderosis and haemochromatosis of synovial tissues.

Immunolocalization of Adhesion Molecules in Rheumatoid and Osteoarthritic Synovial Tissues

Title Immunolocalization of Adhesion Molecules in Rheumatoid and Osteoarthritic Synovial Tissues Author(s) Aoyagi, Takahiko; Eguchi, Katsumi; Nakashima, Munetoshi; Ida, Hiroaki; Furuichi, Itaru; Maeda, Kenji; Nagataki, Shigenobu; Iwasaki, Katsuro Citation Acta medica Nagasakiensia. 1993, 38(2-4), p.62-70 Issue Date 1993-12-25 URL http://hdl.handle.net/10069/15909 Right NAOSITE: Nagasaki Univers...

Disease-specific expression patterns of proteases in synovial tissues.

UNLABELLED To assess whether protease expression patterns can be discriminated according to matrix degradation mechanisms in aseptic prosthesis loosening (APL), rheumatoid arthritis (RA), and osteoarthritis (OA), we immunohistochemically examined the expressions of matrix metalloproteinase-1 and cathepsins B, D, and L in periprosthetic synovial-like interface tissues from 32 patients with faile...

Diffusion of ertapenem into bone and synovial tissues.

OBJECTIVES The degree of penetration of an antibiotic into the infected site is an important criterion for therapeutic success. Ertapenem is a new carbapenem, exhibiting activity against most Gram-positive and Gram-negative aerobic and anaerobic bacteria commonly recovered from community-acquired infections. However, no studies concerning its diffusion into bone and synovial tissue are availabl...